abstract：OBJECTIVE:To characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms. METHODS:Hundred-and-nineteen pat...

journal_title：Journal of neurology

authors： Tommasin S,De Giglio L,Ruggieri S,Petsas N,Giannì C,Pozzilli C,Pantano P

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, autoimmune-inflammatory disease of the peripheral nervous system. Recently, various immunoglobulin G4 (IgG4) type auto-antibodies have been described in patients with CIDP which can effectively be removed by immunoadsorption (IA). Therefore, ...

journal_title：Journal of neurology

authors： Dorst J,Ludolph AC,Senel M,Tumani H

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Journal of neurology

authors： Robertson JA,Tallantyre EC

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:PCT is used in the diagnosis of acute neurological syndromes, particularly stroke. We aimed to evaluate PCT abnormalities in patients with acute epileptic seizures or status epilepticus (SE). METHODS:We collected patients undergoing acute PCT for the suspicion of acute ischemic stroke (AIS), who received ...

journal_title：Journal of neurology

authors： Strambo D,Rey V,Rossetti AO,Maeder P,Dunet V,Browaeys P,Michel P

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To examine the efficacy and safety of the therapeutic regimen using oral and intravenous L-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). METHODS:In the presence and absence of an ictus of stroke-like episodes within 6...

journal_title：Journal of neurology

authors： Koga Y,Povalko N,Inoue E,Nakamura H,Ishii A,Suzuki Y,Yoneda M,Kanda F,Kubota M,Okada H,Fujii K

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To assess the overlap of and differences between quantitative muscle MRI and ultrasound in characterizing structural changes in leg muscles of facioscapulohumeral muscular dystrophy (FSHD) patients. METHODS:We performed quantitative MRI and quantitative ultrasound of ten leg muscles in 27 FSHD patients and a...

journal_title：Journal of neurology

authors： Mul K,Horlings CGC,Vincenten SCC,Voermans NC,van Engelen BGM,van Alfen N

更新日期：2018-11-01 00:00:00

abstract：:Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of s...

journal_title：Journal of neurology

authors： Honrath P,Dogan I,Wudarczyk O,Görlich KS,Votinov M,Werner CJ,Schumann B,Overbeck RT,Schulz JB,Landwehrmeyer BG,Gur RE,Habel U,Reetz K,Enroll-HD investigators.

更新日期：2018-11-01 00:00:00

abstract：:The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently dem...

journal_title：Journal of neurology

authors： Denis HL,Lamontagne-Proulx J,St-Amour I,Mason SL,Weiss A,Chouinard S,Barker RA,Boilard E,Cicchetti F

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Recent research has convincingly shown that the ability to work mainly depends on the cognitive status in multiple sclerosis (MS). An international committee of experts recommended a brief neuropsychological battery to evaluate cognitive performance in MS. BICAMS comprises three tests, the Symbol Digit Modal...

journal_title：Journal of neurology

authors： Filser M,Schreiber H,Pöttgen J,Ullrich S,Lang M,Penner IK

更新日期：2018-11-01 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune encephalitis presenting with psychosis, dyskinesias, autonomic dysfunction and seizures. The underlying autoantibodies against the NR1 subunit are directly pathogenic by disrupting synaptic NMDAR currents. However, antibody titers correlate...

journal_title：Journal of neurology

authors： Ly LT,Kreye J,Jurek B,Leubner J,Scheibe F,Lemcke J,Wenke NK,Reincke SM,Prüss H

更新日期：2018-11-01 00:00:00

abstract：:Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of r...

journal_title：Journal of neurology

authors： van Lith BJH,Coppens MJM,Nonnekes J,van de Warrenburg BPC,Geurts AC,Weerdesteyn V

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The mechanisms of early neurologic deterioration (END) and prevention strategies for END are not completely understood. The aim of this study was to investigate the association between CYP2C19*2 variants and END, and the effectiveness of antiplatelet therapy for prevention of END according to CYP2C19*2 genot...

journal_title：Journal of neurology

authors： Yi X,Zhou Q,Wang C,Lin J,Chai Z

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that still lacks reliable diagnostic biomarkers. This study aims to evaluate the diagnostic and prognostic potential of CSF total Tau (t-Tau), phospho-Tau (p-Tau) and p-Tau/t-Tau ratio in ALS patients using CSF neurofilament light (NFL)...

journal_title：Journal of neurology

authors： Scarafino A,D'Errico E,Introna A,Fraddosio A,Distaso E,Tempesta I,Morea A,Mastronardi A,Leante R,Ruggieri M,Mastrapasqua M,Simone IL

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Tumefactive demyelinating lesions of the central nervous system can be the initial presentation in various pathological entities [multiple sclerosis (the most common), Balo's concentric sclerosis, Schilder's disease and acute disseminated encephalomyelitis] with overlapping clinical presentation. The aim of ...

journal_title：Journal of neurology

authors： Balloy G,Pelletier J,Suchet L,Lebrun C,Cohen M,Vermersch P,Zephir H,Duhin E,Gout O,Deschamps R,Le Page E,Edan G,Labauge P,Carra-Dallieres C,Rumbach L,Berger E,Lejeune P,Devos P,N'Kendjuo JB,Coustans M,Auffray-Calv

更新日期：2018-10-01 00:00:00

abstract：:Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict...

journal_title：Journal of neurology

authors： Amboni M,Iuppariello L,Iavarone A,Fasano A,Palladino R,Rucco R,Picillo M,Lista I,Varriale P,Vitale C,Cesarelli M,Sorrentino G,Barone P

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence and risk factors for paroxysmal atrial fibrillation (PAF) diagnosis in non- cryptogenic ischemic stroke (CIS) patients. METHODS:In this pilot-prospective cohort study of non-CIS patients from September 2014 to September 2017, 53 patients were enrolled. 51/53 patients were implante...

journal_title：Journal of neurology

authors： Katz JM,Eng MS,Carrazco C,Patel AV,Jadonath R,Gribko M,Arora R,Libman RB

更新日期：2018-10-01 00:00:00

abstract：:Rituximab, a monoclonal antibody to CD20, is an effective treatment for relapsing remitting multiple sclerosis (MS) reducing relapse rate by at least 50% over time. Although the mechanism for this clinical benefit is unclear, rituximab depletes circulating B cells, which can perform antigen presentation and stimulatio...

journal_title：Journal of neurology

authors： Baber U,Bouley A,Egnor E,Sloane JA

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The cerebellum is a predilection site of pathology in progressive multiple sclerosis (PMS) patients, contributing to cognitive deficits. Aim of this study was to investigate lobular cerebellar functional connectivity (FC) in PMS patients in relation to cognition. METHODS:In this cross-sectional study, resti...

journal_title：Journal of neurology

authors： Cocozza S,Pontillo G,Russo C,Russo CV,Costabile T,Pepe A,Tedeschi E,Lanzillo R,Brescia Morra V,Brunetti A,Inglese M,Petracca M

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Epilepsy in children negatively impacts on caregiver quality of life (QOL). The study aimed to evaluate the relationships between patient factors [demographics, clinical factors, health-related quality of life (HRQL)], contextual factors (socio-economic factors), caregiver mood, and caregiver QOL, and whethe...

journal_title：Journal of neurology

authors： Jain P,Subendran J,Smith ML,Widjaja E,PEPSQOL Study Team.

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early onset neurodegenerative disease that typically results in ataxia, upper motor neuron dysfunction and sensorimotor peripheral neuropathy. Dysarthria and dysphagia are anecdotally described as key features of ARSACS but the natu...

journal_title：Journal of neurology

authors： Vogel AP,Rommel N,Oettinger A,Stoll LH,Kraus EM,Gagnon C,Horger M,Krumm P,Timmann D,Storey E,Schöls L,Synofzik M

更新日期：2018-09-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to b...

journal_title：Journal of neurology

authors： Marshall I,Thrippleton MJ,Bastin ME,Mollison D,Dickie DA,Chappell FM,Semple SIK,Cooper A,Pavitt S,Giovannoni G,Wheeler-Kingshott CAMG,Solanky BS,Weir CJ,Stallard N,Hawkins C,Sharrack B,Chataway J,Connick P,Chandran S

更新日期：2018-08-01 00:00:00

abstract：AIM:To investigate whether primary lateral sclerosis (PLS) represents part of the amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum of diseases. METHODS:Comprehensive assessment was taken on 21 patients with PLS and results were compared to patients diagnosed with pure motor ALS (n = 27) and ALS...

journal_title：Journal of neurology

authors： Agarwal S,Highton-Williamson E,Caga J,Matamala JM,Dharmadasa T,Howells J,Zoing MC,Shibuya K,Geevasinga N,Vucic S,Hodges JR,Ahmed RM,Kiernan MC

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Near occlusion (NO) of the internal carotid artery (ICA) with full collapse (NOFC) is a rare condition, with a prevalence of around 1%. Guidelines on carotid stenosis recommend a conservative treatment in patients with a single-event ipsilateral to a NOFC, but the optimal treatment for patients with recurrent...

journal_title：Journal of neurology

authors： Meershoek AJA,Vonken EPA,Nederkoorn PJ,Kappelle LJ,de Borst GJ

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Recently, therapeutic attempts to control motor choreatic hyperkinesia of Huntington's disease (HD) by means of pallidal deep brain stimulation (Gp-DBS) were successful. With respect to the clinical effects of Gp-DBS in juvenile hypokinetic-rigid HD (jHD; Westphal variant), only one single-case has been repo...

journal_title：Journal of neurology

authors： Ferrea S,Groiss SJ,Elben S,Hartmann CJ,Dunnett SB,Rosser A,Saft C,Schnitzler A,Vesper J,Wojtecki L,Surgical Approaches Working Group of the European Huntington’s Disease Network (EHDN).

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:The variability of the severity and regional distribution of pathological process in basal ganglia (BG) and brainstem-cerebellar systems results in clinical heterogeneity and represents the motor subtype of multiple system atrophy (MSA). This study aimed to quantify spatial patterns of multimodal MRI abnormal...

journal_title：Journal of neurology

authors： Lee MJ,Kim TH,Mun CW,Shin HK,Son J,Lee JH

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...

journal_title：Journal of neurology

authors： Tan X,Guo Y,Dun S,Sun H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin is intranasal (IN) insulin. The aim of this systematic review is to investi...

journal_title：Journal of neurology

authors： Avgerinos KI,Kalaitzidis G,Malli A,Kalaitzoglou D,Myserlis PG,Lioutas VA

更新日期：2018-07-01 00:00:00

abstract：:Vanishing white matter disease (VWM) is one of the most prevalent inherited leukoencephalopathies in childhood. Infantile VWM is more severe but less understood than the classic early childhood type. We performed a follow-up study on 14 infantile and 26 childhood patients to delineate the natural history and neuroimag...

journal_title：Journal of neurology

authors： Zhou L,Zhang H,Chen N,Zhang Z,Liu M,Dai L,Wang J,Jiang Y,Wu Y

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. OBJECTIVE:To study functional and structural brain changes induced by gait rehabilitation. METHODS:We enrolled MS inpatient...

journal_title：Journal of neurology

authors： Tavazzi E,Bergsland N,Cattaneo D,Gervasoni E,Laganà MM,Dipasquale O,Grosso C,Saibene FL,Baglio F,Rovaris M

更新日期：2018-06-01 00:00:00

abstract：:We aimed to assess the intrasubject reproducibility of a technology-based levodopa (LD) therapeutic monitoring protocol administered in supervised versus unsupervised conditions in patients with Parkinson's disease (PD). The study design was pilot, intrasubject, single center, open and prospective. Twenty patients wer...

journal_title：Journal of neurology

authors： Lopane G,Mellone S,Corzani M,Chiari L,Cortelli P,Calandra-Buonaura G,Contin M

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for ...

journal_title：Journal of neurology

authors： Rosenbohm A,Hirsch S,Volk AE,Grehl T,Grosskreutz J,Hanisch F,Herrmann A,Kollewe K,Kress W,Meyer T,Petri S,Prudlo J,Wessig C,Müller HP,Dreyhaupt J,Weishaupt J,Kubisch C,Kassubek J,Weydt P,Ludolph AC

更新日期：2018-05-01 00:00:00

abstract：:Cardiac conduction and/or rhythm abnormalities (CCRA) are the most frequent and life-threatening complications in DM1. In order to determine prevalence, incidence, characteristics, age of onset and predictors of CCRA, CCRA progression and sudden cardiac death (SCD) in DM1, we collected ECG/24hECG-Holter data from a ye...

journal_title：Journal of neurology

authors： Bucci E,Testa M,Licchelli L,Frattari A,El Halabieh NA,Gabriele E,Pignatelli G,De Santis T,Fionda L,Vanoli F,Morino S,Garibaldi M,Di Pasquale A,Vanacore N,Botta A,Antonini G

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:D-dimer levels are used in several clinical settings, such as in predicting venous thrombosis, cardioembolic stroke and cancer status. In the present study, we investigated the associations between plasma D-dimer levels at admission, clinical characteristics and mortality at discharge in cryptogenic stroke p...

journal_title：Journal of neurology

authors： Nezu T,Kitano T,Kubo S,Uemura J,Yamashita S,Iwanaga T,Inoue T,Hosomi N,Maruyama H,Matsumoto M,Kimura K,Yagita Y

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Cognitive impairment is a debilitating symptom experienced by ~ 50% of multiple sclerosis patients, with processing speed (PS) and memory most affected. Until now, the field has considered cognition in a binary fashion: patients are designated as impaired or not impaired. This designation is typically arrive...

journal_title：Journal of neurology

authors： Leavitt VM,Tosto G,Riley CS

更新日期：2018-03-01 00:00:00

abstract：:Corticobasal degeneration (CBD) was first described by Rebeiz et al. in 1967, and was called corticodentatonigral degeneration with neuronal achromasia [1]. Since then, our knowledge of the clinical features and underlying tau pathology has grown tremendously. Clinical antemortem diagnosis of CBD pathology remains cha...

journal_title：Journal of neurology

authors： Ali F,Josephs KA

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in s...

journal_title：Journal of neurology

authors： Pelz JO,Harms K,Metze M,Michalski D

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To develop specific diagnostic ultrasound (US) models for hereditary motor and sensory neuropathies (HMSN) in patients with primarily demyelinating or axonal polyneuropathies (PNP) according to standard nerve conduction studies (NCS) criteria. METHODS:Single-centre, examiner-blinded cross-sectional study in ac...

journal_title：Journal of neurology

authors： Loewenbrück KF,Dittrich M,Böhm J,Klingelhöfer J,Baum P,Schäfer J,Reichmann H,Hermann A,Storch A

更新日期：2018-01-01 00:00:00

abstract：:Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer's disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and...

journal_title：Journal of neurology

authors： Jang H,Park SB,Kim Y,Kim KW,Lee JI,Kim ST,Lee KH,Kang ES,Choe YS,Seo SW,Kim HJ,Kim YJ,Yoon CW,Na DL

更新日期：2018-01-01 00:00:00

abstract：:Discontinuation of natalizumab can lead to severe rebound of disease activity in patients with relapsing-remitting multiple sclerosis (RRMS); nevertheless, the treatment regimen in this clinical situation remains controversial. We report the case of a 25-year-old male patient with RRMS who was clinically stable under ...

journal_title：Journal of neurology

authors： Uphaus T,Oberwittler C,Groppa S,Zipp F,Bittner S

更新日期：2017-12-01 00:00:00

abstract：:The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assesse...

journal_title：Journal of neurology

authors： Villanueva V,Holtkamp M,Delanty N,Rodriguez-Uranga J,McMurray R,Santagueda P

更新日期：2017-11-01 00:00:00